The authors say that previous clinical reports indicate that the ABO blood group system is involved in determining susceptibility to COVID-19 and is also involved in susceptibility to SARS and CoV-1. Further analysis showed that positive participants had a 45% increased risk of respiratory arrest, while those with blood type O had a 35% reduced risk. The leading SNP was identified in the blood of the positive and negative participants as well as the negative group.
Karlsen's team says that the identification of this variant could help in the targeted research of severe COVID-19 pathophysiology. Investigating people more susceptible to SARS and CoV-2 could help identify and protect at-risk groups and increase the speed of treatment and drug development.
Research published last week ahead of the peer review suggests the blood group could play an important role in the development of SARS, CoV-2 and COVID-19. Several other studies looking at the severity of the disease and susceptibility to disease also suggest that blood groups play a role.
The study examined the relationship between the ABO blood group and those who had respiratory diseases. The study found that this type of blood was associated with an increase in the number of patients needing a ventilator.
The study also found that the difference in the rhesus factor between blood groups did not affect which blood group protected against the COVID-19 virus. Looking only at exposed subjects, those who were in the O blood group were more likely to test positive for the CoVID-19 virus than those with the ABO blood group. Given the number of people exposed to the virus and the proportion of cases in each of the layers, 23andMe found no evidence that any blood group was more protective in either strategy, but the proportion of cases was higher.
By comparing participants who reported having tested positive for COVID-19 with those who tested negative, the researchers identified variants in the ABO gene that were associated with a lower risk. Although it is very early in this study, the preliminary study of 23andMe's genetics appears to support these findings. The study is being reviewed by 23 andMe scientists, who have yet to figure out what the genetic data actually says.
Italian and Spanish studies found no association between blood type and the severity of the disease. One study in China also looked at susceptibility, while another Italian-Spanish study found an association with blood groups and the severity of the disease, but not the severity.
We know from other studies that the ABO blood group plays a direct role in serving as a receptor or coreceptor for microorganisms, parasites and viruses. We wanted to find out if this means that it is responsible for the co-occurrence of the CoV-19 virus.
People with this blood group are more likely to test positive for Covid-19 than people with other blood groups. That's according to an existing database of blood samples from the US Centers for Disease Control and Prevention (CDC). Type O blood appears to be more susceptible to infection with the virus than type B blood, which is less susceptible.
They created a limited set of samples with only those with high viral exposure and found that patients of the blood group had higher infection rates and tended to develop more severe symptoms. Blood type O was found to be more likely to infect viruses than blood type B, but not blood type C. While the researchers say the study is preliminary and more work is needed, they urge governments and medical institutions to take blood group differences into account when planning mitigation and treating patients with Sars and CoV-2.
The ABO blood group, with its long, evidence-based history of a variety of infectious diseases, including smallpox, plague, cholera, and flu, is the most common blood group in the United States and one of the most vulnerable in the world.
The authors found that hospital staff with blood type O had a lower risk of infection than non-O blood groups. A study also found no difference in the number of cases of hepatitis B and C among those who had blood in groups O. O has been identified as an antibody that can block the interaction between the virus and its receptors, providing protection.
To date, only two studies have investigated the association between blood type O and the presence of Covid-19 antibodies in the blood of patients with hepatitis B and C. Here we investigate the association between the number of hepatitis C cases in patients admitted to Qatif Central Hospital (QCH) and the blood group The researchers, who analyzed blood samples from patients who tested positive for Covids 19, conducted their study at Wuhan University's Zhongnan Hospital.
They found that of the 3,694 healthy people studied in Wuhan, only 1.5% had blood type A, while those with the same blood groups had a higher number of hepatitis B and C, showing an association between the presence of Covid-19 antibodies in the blood of patients with hepatitis C. This corresponds to a ratio of 2.2 cases per 1,000 healthy patients. While 33% to 84% of the healthy population are of this blood type O, a total of 3.6 million people live in Qatif and Qichuan.
Sources:
https://www.health24.com/Medical/Infectious-diseases/Coronavirus/one-blood-type-seems-to-be-more-resistant-against-covid-19-20200613-2
https://www.news-medical.net/news/20200603/Blood-group-type-may-affect-susceptibility-to-COVID-19-respiratory-failure.aspx
https://dadamo.com/dangerous/2020/03/20/covid-19-blood-type/
https://www.inventiva.co.in/stories/priyankaraj/blood-group-o-is-less-susceptible-to-covid-19-virus/
https://theprint.in/health/blood-type-plays-role-in-covid-infection-o-group-less-susceptible-study-shows/438156/
https://africacheck.org/spot-check/study-found-people-with-blood-type-a-at-higher-risk-of-covid-19-but-results-preliminary-no-peer-review-yet/
https://blog.23andme.com/23andme-research/23andme-finds-evidence-that-blood-type-plays-a-role-in-covid-19/
https://m.scirp.org/papers/100795
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